冷杉属植物化学成分及其药理活性研究进展

谢晓艳, 周青青, 朱佳雯, 潘巍巍, 占扎君, 谢宝刚, 周武, 徐金标

中国药学杂志 ›› 2023, Vol. 58 ›› Issue (14) : 1245-1264.

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中国药学杂志
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中国药学杂志 ›› 2023, Vol. 58 ›› Issue (14) : 1245-1264. DOI: 10.11669/cpj.2023.14.001
综述

冷杉属植物化学成分及其药理活性研究进展

  • 谢晓艳1,2, 周青青1,2, 朱佳雯1,2, 潘巍巍1, 占扎君2, 谢宝刚1, 周武1*, 徐金标1*
作者信息 +

Progress in Research on Chemical Constituents and Pharmacological Activities of Abies

  • XIE Xiao-yan1,2, ZHOU Qing-qing1,2, ZHU Jia-wen1,2, PAN Wei-wei1, ZHAN Zha-jun2, XIE Bao-gang1, ZHOU Wu1*, XU Jin-biao1*
Author information +
文章历史 +

摘要

冷杉属植物全球已发现有50余种,我国冷杉资源丰富,有19种3变种,主要分布在云南、四川、甘肃和西藏等地区。自2008年以来,文献已报道了17种冷杉属植物中的700多个化合物,其化学成分主要包括萜类、黄酮类、木脂素类、酚类、少量生物碱类、甾体类、蒽醌类和其他类型化合物,具有抗肿瘤、抗炎、抗菌、抗病毒等药理活性。笔者将对2008年以来冷杉属植物化学成分及药理活性的研究进展进行综述,以期为更多创新药物新化学实体的发现提供参考,并为该属植物珍稀资源的合理开发利用提供科学指导。

Abstract

There are about 50 species of Abies, including 19 species and 3 varieties in China, which mainly distribute in Yunnan, Sichuan, Gansu, and Xizang provinces. Since 2008, more than 700 compounds from 17 species of Abies have been reported in the literature. The chemical compositions mainly include terpenoids, flavonoids, lignans, phenols, a small number of alkaloids, steroids, anthraquinones and other compounds, which show anti-tumor, anti-inflammatory, anti-bacterial, anti-viral and other pharmacological activities. This article reviews the chemical constituents and pharmacological activities of components from Abies reported since 2008. In order to provide reference for the discovery of more new chemical entities of innovative drugs, and provide scientific guidance for the rational development and utilization of rare resources of this genus.

关键词

冷杉属 / 萜类 / 黄酮类 / 木脂素类 / 抗肿瘤

Key words

Abies / terpenoid / flavonoid / lignan / anti-tumor

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谢晓艳, 周青青, 朱佳雯, 潘巍巍, 占扎君, 谢宝刚, 周武, 徐金标. 冷杉属植物化学成分及其药理活性研究进展[J]. 中国药学杂志, 2023, 58(14): 1245-1264 https://doi.org/10.11669/cpj.2023.14.001
XIE Xiao-yan, ZHOU Qing-qing, ZHU Jia-wen, PAN Wei-wei, ZHAN Zha-jun, XIE Bao-gang, ZHOU Wu, XU Jin-biao. Progress in Research on Chemical Constituents and Pharmacological Activities of Abies[J]. Chinese Pharmaceutical Journal, 2023, 58(14): 1245-1264 https://doi.org/10.11669/cpj.2023.14.001
中图分类号： R914   

参考文献

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基金

国家自然科学基金项目资助(82003612);创新嘉兴优才支持计划资助(202106)
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